Vikram University was established in Ujjain on 1 March 1957. Shri Ranchod Lalji Dhabai donated the land for it from Barnagar. The foundation stone of Vikram University was laid by the then Home Minister of India Shri Govind Vallabh Pant on 23 October 1956. The function was presided over by the Rajpramukh of Madhya Bharat State Late Jiwajirao Scindia.
The state of Madhya Pradesh was formed in 1956, and Madhya Bharat was merged into it. The Act relating to the University was accordingly amended. The amended Act of Vikram University No. 13, 1957 was published in Madhya Pradesh Gazette on 16 August 1957.
The University's jurisdiction diminished due to the 1964-65 formation of Indore University, Gwalior and Bhopal University during 1969-70. On 20 April 1973, the Governor granted permission to bring about homogeneity in the organization and administration of Madhya Pradesh Universities. This permission was first published in the Madhya Pradesh Gazette (extraordinary) on 23 April 1973. By a notification of the Education Department 940/20/8/71 dated 3 May 1973, the by-laws of the Madhya Pradesh Universities Act No. 1 to 19 were brought into effect from 25 September 1973, No. 20 to 26 from 1 December 1973, and No. 27 to 31 from 4 May 1974, for all the Universities of Madhya Pradesh (including Vikram University).
The Madhya Pradesh Universities Act was amended and published in Madhya Pradesh Gazette on 28 June 1985. As per the amendment, University Jurisdiction was redefined and demarcated in accordance with the Revenue districts of Ujjain Division, including Ujjain, Ratlam, Mandsaur, Neemuch, Shajapur and Dewas. Because of the new jurisdiction, the number of affiliated colleges decreased, and some new colleges were granted affiliation.